(19)

(11)

EP 0 633 781 A1

(12)

(43) Date of publication: 18.01.1995 Bulletin 1995/03 (21) Application number: 93908738.0 (22) Date of filing: 02.04.1993

(51) International Patent Classification (IPC):  A61K 45/ 06( . ) A61K 31/ 475( . ) A61K 31/ 56( . ) A61P 15/ 00( . ) A61K 31/ 205( . ) A61K 31/ 505( . ) A61P 13/ 02( . ) (86) International application number: PCT/US1993/003145 (87) International publication number: WO 1993/019758 (14.10.1993 Gazette 1993/25)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 02.04.1992 US 19920862117 29.12.1992 US 19920997792 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406-0939 (US)	(72) Inventors: HIEBLE, Jacob Paul Wayne, PA 19087 (US) METCALF, Brian Walter Radnor, PA 19087 (US) (74) Representative: Florence, Julia Anne  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)