(19)

(11)

EP 0 636 132 A1

(12)

(43) Date of publication: 01.02.1995 Bulletin 1995/05 (21) Application number: 93909506.0 (22) Date of filing: 15.04.1993

(51) International Patent Classification (IPC):  C07D 241/ 36( . ) A61K 31/ 403( . ) A61K 31/ 44( . ) A61K 31/ 443( . ) A61K 31/ 50( . ) A61P 25/ 00( . ) C07D 209/ 96( . ) C07D 401/ 14( . ) C07D 405/ 14( . ) C07D 471/ 04( . ) A61K 31/ 40( . ) A61K 31/ 415( . ) A61K 31/ 4427( . ) A61K 31/ 4433( . ) A61K 31/ 505( . ) A61P 25/ 28( . ) C07D 241/ 38( . ) C07D 403/ 14( . ) C07D 409/ 14( . ) C07D 471/ 10( . ) (86) International application number: PCT/US1993/003391 (87) International publication number: WO 1993/021185 (28.10.1993 Gazette 1993/26)

(84) Designated Contracting States: DE FR GB IT (30) Priority: 16.04.1992 US 19920869163 (71) Applicant: THE DU PONT MERCK PHARMACEUTICAL COMPANY Wilmington, Delaware 19898 (US)	(72) Inventors: ABELMAN, Matthew Mark Solano Beach, CA 92075 (US) BRITTELLI, David, Ross Nottingham, PA 19362-9603 (US) NUGIEL, David, Alan Philadelphia, PA 19147 (US) VOSS, Matthew, Ernst Lincoln University, PA 19352 (US) (74) Representative: von Kreisler, Alek, Dipl.-Chem., et al  Patentanwälte, von Kreisler-Selting-Werner, Bahnhofsvorplatz 1 (Deichmannhaus) D-50667 Köln D-50667 Köln (DE)