(19)

(11)

EP 0 637 303 A1

(12)

(43) Date of publication: 08.02.1995 Bulletin 1995/06 (21) Application number: 93909052.0 (22) Date of filing: 15.04.1993

(51) International Patent Classification (IPC):  C07D 295/ 08( . ) A61K 31/ 443( . ) A61P 9/ 00( . ) A61P 43/ 00( . ) C07C 323/ 09( . ) C07D 211/ 14( . ) C07D 213/ 06( . ) C07D 295/ 092( . ) C07D 311/ 82( . ) C07D 317/ 64( . ) C07D 405/ 12( . ) A61K 31/ 4418( . ) A61K 31/ 445( . ) A61P 9/ 10( . ) C07C 43/ 225( . ) C07C 323/ 19( . ) C07D 211/ 46( . ) C07D 295/ 088( . ) C07D 307/ 91( . ) C07D 317/ 62( . ) C07D 335/ 12( . ) (86) International application number: PCT/GB1993/000801 (87) International publication number: WO 1993/022302 (11.11.1993 Gazette 1993/27)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.04.1992 GB 19920008871 24.04.1992 GB 19920008859 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford, Middlesex TW8 9EP (GB)

(72) Inventors: BROWN, Thomas, Henry SmithKline Beecham Pharm. Essex CM19 5AD (GB) COOPER, David, Gwyn SmithKline Beecham Pharm. Essex CM19 5AD (GB) KING, Ronald, Joseph SmithKline Beecham Pharm. Essex CM19 5AD (GB) (74) Representative: Florence, Julia Anne, et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)