SPECIFIC INHIBITION OF DIHYDROFOLATE REDUCTASE AND COMPOUNDS THEREFOR - Patent 0639075

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EP 0 639 075 A1

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(43)	Date of publication:
	22.02.1995 Bulletin 1995/08

(21)	Application number: 92900837.0

(22)	Date of filing: 14.11.1991

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International Patent Classification (IPC):

C07D 239/ 48^{( . )}
A61P 31/ 04^{( . )}

A61K 31/ 505^{( . )}
C07D 487/ 04^{( . )}

(86)	International application number:
	PCT/US1991/008515

(87)	International publication number:
	WO 1992/008461 (29.05.1992 Gazette 1992/12)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IT LI LU NL SE

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Priority:

14.11.1990 US 19900613619
16.07.1991 US 19910730691

(71)	Applicant: CHIRON CORPORATION
	Emeryville California 94608-2916 (US)

(72)	Inventors:
	KOMPIS, Ivan Basel (CH) BLANEY, Jeffrey, M. Oakland, CA 94611 (US) MARLOW, Charles, K. San Francisco, CA 94131 (US)

(74)	Representative: Goldin, Douglas Michael, et al
	J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)

(54)	SPECIFIC INHIBITION OF DIHYDROFOLATE REDUCTASE AND COMPOUNDS THEREFOR