(19)

(11)

EP 0 639 194 A1

(12)

(43) Date of publication: 22.02.1995 Bulletin 1995/08 (21) Application number: 92901579.0 (22) Date of filing: 05.01.1992

(51) International Patent Classification (IPC):  A61K 31/ 335( . ) C07D 493/ 08( . ) A61P 3/ 06( . ) (86) International application number: PCT/EP1992/000016 (87) International publication number: WO 1992/012158 (23.07.1992 Gazette 1992/19)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI NL SE (30) Priority: 09.01.1991 GB 19910004242 07.08.1991 GB 19910171512 (71) Applicant: GLAXO GROUP LIMITED Greenford, Middlesex UB6 0NN (GB)

(72) Inventors: SIDEBOTTOM, Philip, James Greenford Middlesex UB6 0HE (GB) LESTER, Michael, George Greenford Middlesex UB6 0HE (GB) PROCOPIOU, Panayiotis, Alexandrou Greenford Middlesex UB6 0HE (GB) WATSON, Nigel, Stephen Greenford Middlesex UB6 0HE (GB) BIONDI, Stefano Via Alessandro Fleming, 2 I-37100 Verona (IT) RAMSAY, Michael, Vincent, John Greenford Middlesex UB6 0HE (GB) LIVERMORE, David, George, Hubert Greenford Middlesex UB6 0HE (GB) ROSS, Barry, Clive Glaxo Group Research Limited Greenford Middlesex UB6 0HE (GB) (74) Representative: Caffin, Lee, et al  Glaxo Holdings plc Glaxo House Berkeley Avenue Greenford, Middlesex UB6 0NN Greenford, Middlesex UB6 0NN (GB)