(19)

(11)

EP 0 639 226 A1

(12)

(43) Date of publication: 22.02.1995 Bulletin 1995/08 (21) Application number: 91912361.0 (22) Date of filing: 25.06.1991

(51) International Patent Classification (IPC):  C07K 14/ 82( . ) A61K 38/ 00( . ) C12N 15/ 113( . ) (86) International application number: PCT/US1991/004545 (87) International publication number: WO 1992/000080 (09.01.1992 Gazette 1992/02)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 26.06.1990 US 19900544199 (71) Applicant: THE WISTAR INSTITUTE Philadelphia Pennsylvania 19104-4268 (US)	(72) Inventors: REDDY, Premkumar Villanova, PA 19085 (US) SHORE, Scott Ardmore, PA 19003 (US) (74) Representative: Hale, Stephen Geoffrey, et al  J.Y. & G.W. Johnson Furnival House 14/18 High Holborn London WC1V 6DE London WC1V 6DE (GB)