(19)

(11)

EP 0 640 091 A1

(12)

(43) Date of publication: 01.03.1995 Bulletin 1995/09 (21) Application number: 93911072.0 (22) Date of filing: 06.05.1993

(51) International Patent Classification (IPC):  C07D 473/ 18( . ) C07D 473/ 00( . ) C07H 19/ 06( . ) C07H 19/ 173( . ) C07D 405/ 04( . ) C07D 473/ 34( . ) C07H 19/ 16( . ) (86) International application number: PCT/US1993/004239 (87) International publication number: WO 1993/023413 (25.11.1993 Gazette 1993/28)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 13.05.1992 US 19920882479 13.05.1992 US 19920882572 08.07.1992 US 19920910649 24.07.1992 US 19920919544 (71) Applicant: RIBOZYME PHARMACEUTICALS, INC. Boulder, CO 80301 (US)	(72) Inventors: BEIGELMAN, Leonid Boulder, CO 80301 (US) MATULIC-ACADEMIC, Jasenka Boulder, CO 80303 (US) (74) Representative: Goldin, Douglas Michael  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)