(19)

(11)

EP 0 640 147 A1

(12)

(43) Date of publication: 01.03.1995 Bulletin 1995/09 (21) Application number: 93911141.0 (22) Date of filing: 07.05.1993

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12Q 1/ 68( . ) (86) International application number: PCT/US1993/004330 (87) International publication number: WO 1993/022463 (11.11.1993 Gazette 1993/27)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.05.1992 US 19920880145 (71) Applicant: IG LABORATORIES INC. Framingham, MA 01701 (US)	(72) Inventor: HOUSEAL, Timothy, W. Hopkinton, MA 01748 (US) (74) Representative: Froud, Clive, et al  Elkington and Fife Prospect House 8 Pembroke Road Sevenoaks, Kent TN13 1XR Sevenoaks, Kent TN13 1XR (GB)