(19)

(11)

EP 0 641 215 A1

(12)

(43) Date of publication: 08.03.1995 Bulletin 1995/10 (21) Application number: 93905821.0 (22) Date of filing: 05.02.1993

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61P 7/ 02( . ) C07K 14/ 575( . ) C12N 15/ 12( . ) C12R 1/ 91( . ) A61K 38/ 00( . ) C07H 21/ 04( . ) C07K 14/ 745( . ) C12P 21/ 02( . ) (86) International application number: PCT/US1993/001120 (87) International publication number: WO 1993/015755 (19.08.1993 Gazette 1993/20)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.02.1992 US 19920830577 (60) Divisional application: 04009293.4 / 1449849 (71) Applicants: SCHERING AKTIENGESELLSCHAFT D-13342 Berlin (DE) Light, David Richard San Mateo, CA 94402 (US)

(72) Inventors: LIGHT, David, Richard San Mateo, CA 94402 (US) ANDREWS, William, H. San Mateo, CA 94404 (US) CLARKE, Jeffrey, Homer Pacifica, CA 94044 (US) WYDRO, Robert, Michael Foster City, CA 94404 (US) YOUNG, Patricia, Ann San Rafael, CA 94901 (US) (74) Representative: König, Gregor Sebastian, et al  König - Palgen - Schumacher - Kluin Patentanwälte Lohengrinstrasse 11 40549 Düsseldorf 40549 Düsseldorf (DE)