CYCLOPENTANE AND CYCLOPENTENE DERIVATIVES WITH ANTIALLERGIC ANTIINFLAMMATORY AND TUMOR NECROSIS FACTOR INHIBITING ACTIVITY - Patent 0642489

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(11)

EP 0 642 489 A1

(12)

(43)	Date of publication:
	15.03.1995 Bulletin 1995/11

(21)	Application number: 92921752.0

(22)	Date of filing: 01.10.1992

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International Patent Classification (IPC):

A61K 31/ 122^{( . )}
A61K 31/ 192^{( . )}
A61K 31/ 216^{( . )}
A61K 31/ 41^{( . )}
A61K 31/ 4409^{( . )}
A61P 29/ 00^{( . )}
A61P 37/ 08^{( . )}
C07C 45/ 68^{( . )}
C07C 49/ 753^{( . )}
C07C 62/ 12^{( . )}
C07C 69/ 734^{( . )}
C07C 217/ 52^{( . )}
C07C 233/ 23^{( . )}
C07C 233/ 43^{( . )}
C07C 237/ 42^{( . )}
C07C 251/ 44^{( . )}
C07C 317/ 22^{( . )}
C07C 323/ 24^{( . )}
C07D 235/ 02^{( . )}

A61K 31/ 165^{( . )}
A61K 31/ 194^{( . )}
A61K 31/ 277^{( . )}
A61K 31/ 4184^{( . )}
A61P 11/ 06^{( . )}
A61P 37/ 00^{( . )}
C07C 45/ 62^{( . )}
C07C 45/ 70^{( . )}
C07C 59/ 72^{( . )}
C07C 62/ 34^{( . )}
C07C 69/ 757^{( . )}
C07C 229/ 48^{( . )}
C07C 233/ 25^{( . )}
C07C 235/ 40^{( . )}
C07C 237/ 44^{( . )}
C07C 255/ 46^{( . )}
C07C 317/ 32^{( . )}
C07D 213/ 40^{( . )}
C07D 257/ 04^{( . )}

(86)	International application number:
	PCT/US1992/008609

(87)	International publication number:
	WO 1993/007111 (15.04.1993 Gazette 1993/10)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE

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Priority:

02.10.1991 US 19910771062

(71)	Applicant: SMITHKLINE BEECHAM CORPORATION
	Philadelphia Pennsylvania 19101 (US)

(72)	Inventors:
	CHRISTENSEN, Siegfried, Benjamin, IV Philadelphia, PA 19103 (US) LEVY, Mark, Alan Wayne, PA 19087 (US)

(74)	Representative: Rutter, Keith, Dr.
	SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)

(54)	CYCLOPENTANE AND CYCLOPENTENE DERIVATIVES WITH ANTIALLERGIC ANTIINFLAMMATORY AND TUMOR NECROSIS FACTOR INHIBITING ACTIVITY