(19)
(11) EP 0 642 500 A1

(12)

(43) Date of publication:
15.03.1995 Bulletin 1995/11

(21) Application number: 93900050.0

(22) Date of filing: 10.12.1992
(51) International Patent Classification (IPC): 
A61K 31/ 47( . )
C07D 215/ 44( . )
 A61P 1/ 04( . )
(86) International application number:
PCT/EP1992/002898
(87) International publication number:
WO 1993/012090 (24.06.1993 Gazette 1993/15)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 12.12.1991 GB 19910026438

(71) Applicant: SMITHKLINE BEECHAM INTERCREDIT B.V.
NL-2280 GC Rijswijk (NL)

(72) Inventors:
  • GRUNDLER, Gerhard
    D-7550 Konstanz (DE)
  • RAINER, Georg
    D-7550 Konstanz (DE)
  • IFE, Robert John
    Welwyn, Hertfordshire AL6 9AR (GB)
  • LEACH, Colin Andrew
    Welwyn, Hertfordshire AL6 9AR (GB)
  • POSTIUS, Stefen
    D-7550 Konstanz (DE)
  • RIEDEL, Richard
    D-7967 Bad Waldsee-Reute (DE)
  • SCHAEFER, Hartmann
    D-7550 Konstanz (DE)
  • SENN-BILFINGER, Jörg
    D-7550 Konstanz (DE)
  • SIMON, Wolfgang, Alexander
    D-7550 Konstanz (DE)

(74) Representative: Giddings, Peter John, Dr. 
SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road
Brentford, Middlesex TW8 9BD
Brentford, Middlesex TW8 9BD (GB)

   


(54) 4-AMINO-3-ACYL QUINOLINE DERIVATIVES AND THEIR USE AS INHIBITORS OF GASTRIC ACID SECRETION