(19)

(11)

EP 0 642 581 A1

(12)

(43) Date of publication: 15.03.1995 Bulletin 1995/11 (21) Application number: 93913200.0 (22) Date of filing: 20.05.1993

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 39/ 395( . ) C07K 14/ 195( . ) C07K 14/ 41( . ) C07K 19/ 00( . ) C12N 9/ 20( . ) C12N 15/ 55( . ) A61K 39/ 00( . ) A61K 39/ 08( . ) A61P 31/ 04( . ) C07K 14/ 33( . ) C07K 16/ 00( . ) C12N 9/ 10( . ) C12N 15/ 31( . ) C12P 21/ 08( . ) C12R 1/ 145( . ) (86) International application number: PCT/GB1993/001039 (87) International publication number: WO 1993/023543 (25.11.1993 Gazette 1993/28)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 20.05.1992 GB 19920010717 23.07.1992 GB 19920015655 (71) Applicant: THE SECRETARY OF STATE FOR DEFENCE IN HER BRITANNIC MAJESTY'S GOVERNMENT OF THE UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN London SW1A 2HB (GB)	(72) Inventors: TITBALL, Richard, William CBDE Porton Down Wiltshire SP4 0JQ (GB) WILLIAMSON, Ethel, Diane Salisbury Wiltshire SP4 0JQ (GB) (74) Representative: Lockwood, Peter Brian  Ministry of Defence (PE), Directorate of Intellectual Property Rights, Room 2012, Empress State Building, Lillie Road London SW6 1TR London SW6 1TR (GB)