(19)

(11)

EP 0 643 578 A1

(12)

(43) Date of publication: 22.03.1995 Bulletin 1995/12 (21) Application number: 94911961.0 (22) Date of filing: 31.03.1994

(51) International Patent Classification (IPC):  A61K 47/ 12( . ) A61K 31/ 135( . ) A61K 47/ 14( . ) A61K 47/ 34( . ) A61K 9/ 20( . ) A61K 31/ 137( . ) A61K 47/ 32( . ) A61K 47/ 44( . ) (86) International application number: PCT/FI1994/000128 (87) International publication number: WO 1994/022435 (13.10.1994 Gazette 1994/23)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 02.04.1993 SE 19930001112 (60) Divisional application: 96110727.3 / 0739628 (71) Applicant: ORION-YHTYMÄ OY SF-02200 Espoo (FI)	(72) Inventors: HALONEN, Matti Aukusti FIN-21290 Rusko (FI) LEINONEN, Ulla Inkeri FIN-20740 Turku (FI) PARHI, Seppo Sulevi Lennart FIN-90810 Kiviniemi (FI) PIIPPO, Ilse Maria FIN-21600 Parainen (FI) ÖRN, Gunilla Margareta FIN-20540 Turku (FI) (74) Representative: Sexton, Jane Helen, et al  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)