(19)

(11)

EP 0 643 727 A1

(12)

(43) Date of publication: 22.03.1995 Bulletin 1995/12 (21) Application number: 93918119.0 (22) Date of filing: 03.06.1993

(51) International Patent Classification (IPC):  G01N 33/ 50( . ) C12Q 1/ 56( . ) C07K 14/ 815( . ) G01N 33/ 86( . ) (86) International application number: PCT/US1993/005315 (87) International publication number: WO 1993/025578 (23.12.1993 Gazette 1993/30)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.06.1992 US 19920893631 22.02.1993 US 19930021033 (71) Applicant: DEPARTMENT OF THE ARMY, U.S. GOVERNMENT Fort Detrick, Frederick, MD 21702-5012 (US)	(72) Inventors: REID, Thomas Rockville, MD 20850 (US) ALVING, Barbara Bethesda, MD 20817 (US) HENDRICKS, Glenna 9669 A Main Street Fairfax, VA 22031 (US) (74) Representative: Harding, Charles Thomas  D. Young & Co. 21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)