(19)

(11)

EP 0 644 940 A1

(12)

(43) Date of publication: 29.03.1995 Bulletin 1995/13 (21) Application number: 93911192.0 (22) Date of filing: 14.05.1993

(51) International Patent Classification (IPC):  C12N 9/ 18( . ) C12P 41/ 00( . ) C12N 15/ 55( . ) F02B 75/ 02( . ) (86) International application number: PCT/US1993/004392 (87) International publication number: WO 1993/023547 (25.11.1993 Gazette 1993/28)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 15.05.1992 US 19920883658 (71) Applicant: SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED Hamilton 11 (BM)

(72) Inventors: CHAN, Hardy W. Palo Alto, CA 94304 (US) FREEDMAN, Richard San Mateo, CA 94404 (US) SALAZAR, Felix, H. Palo Alto, CA 94306 (US) BECK, Steven, R. Boulder, CO 80303 (US) CAIN, Robert, O. Boulder, CO 80303 (US) ROBERTS, Christopher, R. Berthoud, CO 80304 (US) SYNDER, Roger, C. Boulder, CO 80304 (US) PHELPS, Patricia Weir, TX 78674 (US) HEEFNER, Donald, L. Hudson, MA 01749 (US) (74) Representative: Ellis, Edward Lovell  MEWBURN ELLIS York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)