(19)
(11) EP 0 646 010 A1

(12)

(43) Date of publication:
05.04.1995 Bulletin 1995/14

(21) Application number: 93916585.0

(22) Date of filing: 18.06.1993
(51) International Patent Classification (IPC): 
C07K 14/ 575( . )
A61K 38/ 00( . )
C07K 16/ 26( . )
A61K 48/ 00( . )
(86) International application number:
PCT/US1993/005791
(87) International publication number:
WO 1994/000133 (06.01.1994 Gazette 1994/02)
(84) Designated Contracting States:
CH DE DK ES FR GB IE IT LI NL PT SE

(30) Priority: 19.06.1992 US 19920901637
21.01.1993 US 19930007125

(71) Applicant: THE GENERAL HOSPITAL CORPORATION
Boston, MA 02114 (US)

(72) Inventors:
  • DONAHOE, Patricia K.
    Weston, MA 02193 (US)
  • CHIN, Tai Wai
    Taipei, Taiwan 112 (TW)
  • PARRY, Robert L.
    Silver Spring, MD 20910 (US)
  • EPSTEIN, James
    Boston, MA 02114 (US)
  • RAGIN, Richard C.
    Boston, MA 02135 (US)
  • MACLAUGHLIN, David T.
    Saugus, MA 01906 (US)
  • BARKSDALE, Edward M.
    Cincinnati, OH 45236 (US)

(74) Representative: White, Martin Paul, et al 
Kilburn & Strode, 30 John Street
London WC1N 2DD
London WC1N 2DD (GB)

   


(54) USE OF MULLERIAN INHIBITING SUBSTANCE FOR TREATING TUMORS AND FOR MODULATING CLASS 1 MAJOR HISTOCOMPATIBILITY ANTIGEN EXPRESSION