(19)

(11)

EP 0 646 017 A1

(12)

(43) Date of publication: 05.04.1995 Bulletin 1995/14 (21) Application number: 91909691.0 (22) Date of filing: 26.04.1991

(51) International Patent Classification (IPC):  A23C 9/ 00( . ) A61K 39/ 35( . ) C07K 2/ 00( . ) A61K 35/ 20( . ) A61P 37/ 08( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1991/002923 (87) International publication number: WO 1992/000756 (23.01.1992 Gazette 1992/03)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 05.07.1990 US 19900548419 (71) Applicant: THE STOLLE RESEARCH AND DEVELOPMENT CORPORATION Cincinnati Ohio 45242 (US)	(72) Inventors: BECK, Lee, R. Lebanon, OH 45036 (US) STOLLE, Ralph, J. Oregonia, OH 45054 (US) (74) Representative: Wright, Simon Mark, et al  Kilburn & Strode 30 John Street London WC1N 2DD London WC1N 2DD (GB)