(19)

(11)

EP 0 646 032 A1

(12)

(43) Date of publication: 05.04.1995 Bulletin 1995/14 (21) Application number: 93916549.0 (22) Date of filing: 15.06.1993

(51) International Patent Classification (IPC):  A61M 5/ 142( . ) A61M 37/ 00( . ) A61M 5/ 14( . ) A61M 5/ 148( . ) B01J 7/ 02( . ) (86) International application number: PCT/US1993/005736 (87) International publication number: WO 1993/025269 (23.12.1993 Gazette 1993/30)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 15.06.1992 US 19920898259 (71) Applicant: ABBOTT LABORATORIES Abbott Park, Illinois 60064-3500 (US)

(72) Inventors: BRYANT, Peter, L. Libertyville, IL 60048 (US) DRIVAS, Nicolaos, A. Des Plaines, IL 60018 (US) MITTAG, Rodney M. Lake Forest, IL 60045 (US) MOORE, John, K. Highland Park, IL 60035 (US) TRIPP, Edward, S. Antioch, IL 60002 (US) RUDZENA, William, L. McHenry, IL 60050 (US) WILLIAMS, John, C. Union Grove, WI 53182 (US) (74) Representative: Modiano, Guido, Dr.-Ing., et al  Modiano, Josif, Pisanty & Staub, Baaderstrasse 3 D-80469 München D-80469 München (DE)