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(11)

EP 0 646 244 A1

(12)

(43) Date of publication: 05.04.1995 Bulletin 1995/14 (21) Application number: 94914090.0 (22) Date of filing: 08.04.1994

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) C07K 16/ 00( . ) C07K 16/ 40( . ) C12P 21/ 08( . ) G01N 33/ 86( . ) C07K 14/ 81( . ) C07K 16/ 36( . ) C12N 15/ 02( . ) G01N 33/ 573( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1994/003885 (87) International publication number: WO 1994/024566 (27.10.1994 Gazette 1994/24)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IE IT LI NL PT SE (30) Priority: 15.04.1993 US 19930048014 (71) Applicant: BAXTER DIAGNOSTICS INC. Deerfield, IL 60015 (US)

(72) Inventors: MCINERNEY, Margaret Coral Gables, FL 33134 (US) RUIZ, Juan, A. Acton, MA 01720 (US) MILLER, Steve Sunrise, FL 33351 (US) PEREZ-TEJIDOR, Liliana Miami, FL 33185 (US) ARBUTHNOTT, Kathryn, A. Miami, FL 33129 (US) MUSTAIN, Eric, L. Johnson City, TN 37614 (US) (74) Representative: MacGregor, Gordon, et al  ERIC POTTER CLARKSON St. Mary's Court St. Mary's Gate Nottingham, NG1 1LE Nottingham, NG1 1LE (GB)