(19)

(11)

EP 0 647 236 A1

(12)

(43) Date of publication: 12.04.1995 Bulletin 1995/15 (21) Application number: 93912310.0 (22) Date of filing: 16.04.1993

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61P 3/ 08( . ) A61P 9/ 00( . ) A61P 9/ 08( . ) A61P 9/ 12( . ) A61P 13/ 02( . ) A61P 25/ 00( . ) C07K 7/ 06( . ) A61P 1/ 04( . ) A61P 3/ 10( . ) A61P 9/ 04( . ) A61P 9/ 10( . ) A61P 11/ 00( . ) A61P 15/ 00( . ) A61P 35/ 00( . ) C07K 14/ 575( . ) (86) International application number: PCT/US1993/003658 (87) International publication number: WO 1993/021219 (28.10.1993 Gazette 1993/26)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 22.04.1992 US 19920872225 31.03.1993 US 19930033515 (71) Applicant: WARNER-LAMBERT COMPANY Ann Arbor, Michigan 48105 (US)	(72) Inventors: CODY, Wayne, Livingston Saline, MI 48176 (US) DOHERTY, Annette, Marian Ann Arbor, MI 48103 (US) TOPLISS, John, Gordon Ann Arbor, MI 48105 (US) (74) Representative: Mansmann, Ivo  Warner-Lambert Company, Legal Division, Legal Department, c/o Gödecke AG D-79090 Freiburg D-79090 Freiburg (DE)