(19)

(11)

EP 0 648 218 A1

(12)

(43) Date of publication: 19.04.1995 Bulletin 1995/16 (21) Application number: 93914865.0 (22) Date of filing: 01.07.1993

(51) International Patent Classification (IPC):  A61K 31/ 70( . ) A61K 31/ 7052( . ) A61P 31/ 12( . ) A61K 31/ 7042( . ) A61K 31/ 7076( . ) C07H 19/ 16( . ) (86) International application number: PCT/GB1993/001388 (87) International publication number: WO 1994/001443 (20.01.1994 Gazette 1994/03)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 02.07.1992 GB 19920014171 05.11.1992 GB 19920023180 (71) Applicant: THE WELLCOME FOUNDATION LIMITED London NW1 2BP (GB)	(72) Inventors: KOSZALKA, George, Walter Chapel Hill, NC 27514 (US) VAN DRAANEN, Nanine Agneta Durham, NC 27713 (US) FREEMAN, George, Andrew Raleigh, NC 27606 (US) SHORT, Steven, Andersen Cary, NC 27511 (US) (74) Representative: Garrett, Michael, et al  The Wellcome Foundation Limited Group Patents and Agreements Langley Court Beckenham Kent BR3 3BS Beckenham Kent BR3 3BS (GB)