(19)

(11)

EP 0 649 408 A1

(12)

(43) Date of publication: 26.04.1995 Bulletin 1995/17 (21) Application number: 93916841.0 (22) Date of filing: 30.06.1993

(51) International Patent Classification (IPC):  A61K 31/ 44( . ) A61P 43/ 00( . ) C07D 213/ 65( . ) A61K 31/ 4418( . ) C07D 213/ 55( . ) (86) International application number: PCT/US1993/006177 (87) International publication number: WO 1994/000433 (06.01.1994 Gazette 1994/02)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 30.06.1992 US 19920906951 02.03.1993 US 19930025200 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406-0939 (US)	(72) Inventor: DAINES, Robert, A. Lansdale, PA 19446 (US) (74) Representative: Rutter, Keith, Dr., et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)