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(11)

EP 0 649 469 A1

(12)

(43) Date of publication: 26.04.1995 Bulletin 1995/17 (21) Application number: 93916933.0 (22) Date of filing: 02.07.1993

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A01N 63/ 00( . ) C12N 1/ 21( . ) C12N 15/ 52( . ) C12N 15/ 82( . ) A01N 37/ 46( . ) C07K 14/ 21( . ) C12N 15/ 31( . ) C12N 15/ 78( . ) C12R 1/ 39( . ) (86) International application number: PCT/US1993/006300 (87) International publication number: WO 1994/001561 (20.01.1994 Gazette 1994/03)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 02.07.1992 US 19920908284 (71) Applicants: CIBA-GEIGY AG CH-4002 Basel (CH) UNITED STATES DEPARTMENT OF AGRICULTURE Washington, DC 20250 (US)

(72) Inventors: GAFFNEY, Thomas, D. Chapel Hill, NC 27514 (US) LAM, Stephen, T. Raleigh, NC 27613 (US) HILL, Dwight, Steven Cary, NC 27511 (US) STEIN, Jeffrey, I. Hillsborough, NC 27278 (US) HOWELL, Charles, R. Bryan, TX 77802 (US) BECKER, J., Ole Riverside, CA 92506 (US) LIGON, James, M. Cary, NC 27513 (US) (74) Representative: Bastian, Werner Maria, et al  Ciba-Geigy AG, Patentabteilung, Klybeckstrasse 141 CH-4002 Basel CH-4002 Basel (CH)