(19)

(11)

EP 0 650 358 A1

(12)

(43) Date of publication: 03.05.1995 Bulletin 1995/18 (21) Application number: 93916878.0 (22) Date of filing: 30.06.1993

(51) International Patent Classification (IPC):  A61K 31/ 505( . ) C07J 73/ 00( . ) A61K 31/ 58( . ) (86) International application number: PCT/US1993/006233 (87) International publication number: WO 1994/000121 (06.01.1994 Gazette 1994/02)

(84) Designated Contracting States: BE CH DE FR GB IT LI NL (30) Priority: 30.06.1992 GB 19920013901 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406-0939 (US)	(72) Inventors: HOLT, Dennis Alan Mohnton, PA 19540 (US) LEVY, Mark Alan Wayne, PA 19087 (US) OH, Hye-Ja Cheltenham, PA 19012 (US) (74) Representative: Summersell, Richard John  SmithKline Beecham Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)