(19)

(11)

EP 0 650 360 A1

(12)

(43) Date of publication: 03.05.1995 Bulletin 1995/18 (21) Application number: 93914090.0 (22) Date of filing: 27.05.1993

(51) International Patent Classification (IPC):  A61K 31/ 66( . ) A61K 31/ 67( . ) A61P 29/ 00( . ) C07F 9/ 38( . ) C07F 9/ 572( . ) C07F 9/ 62( . ) C07F 9/ 6553( . ) A61K 31/ 665( . ) A61K 31/ 675( . ) C07F 9/ 24( . ) C07F 9/ 40( . ) C07F 9/ 58( . ) C07F 9/ 6512( . ) (86) International application number: PCT/US1993/004891 (87) International publication number: WO 1994/002152 (03.02.1994 Gazette 1994/04)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 16.07.1992 US 19920914840 17.09.1992 US 19920947114 22.10.1992 US 19920965980 (71) Applicant: THE UPJOHN COMPANY Kalamazoo, Michigan 49001 (US)	(72) Inventors: WHITE, David Raymond Kalamazoo, MI 49008 (US) FRITZEN, Edward Lawrence, Jr. Kalamazoo, MI 49001 (US) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)