(19)

(11)

EP 0 650 362 A1

(12)

(43) Date of publication: 03.05.1995 Bulletin 1995/18 (21) Application number: 93915908.0 (22) Date of filing: 13.07.1993

(51) International Patent Classification (IPC):  A61K 31/ 44( . ) A61P 31/ 12( . ) A61K 31/ 505( . ) A61P 37/ 04( . ) (86) International application number: PCT/EP1993/001846 (87) International publication number: WO 1994/002154 (03.02.1994 Gazette 1994/04)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 16.07.1992 GB 19920015176 (71) Applicant: GLAXO GROUP LIMITED Greenford, Middlesex UB6 0NN (GB)	(72) Inventor: CAMERON, Janet Mary Greenford, Middlesex UB6 0HE (GB) (74) Representative: Filler, Wendy Anne, et al  Glaxo Wellcome plc Glaxo House Berkeley Avenue Greenford, Middlesex UB6 0NN Greenford, Middlesex UB6 0NN (GB)