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(11)

EP 0 650 369 A1

(12)

(43) Date of publication: 03.05.1995 Bulletin 1995/18 (21) Application number: 93916056.0 (22) Date of filing: 13.07.1993

(51) International Patent Classification (IPC):  A61K 39/ 00( . ) A61P 31/ 18( . ) A61P 31/ 12( . ) C07K 14/ 74( . ) (86) International application number: PCT/GB1993/001459 (87) International publication number: WO 1994/001130 (20.01.1994 Gazette 1994/03)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 13.07.1992 GB 19920014871 (71) Applicant: MEDICAL RESEARCH COUNCIL London W1N 4AL (GB)

(72) Inventors: STOTT, Edward James, Nat. Inst. for Biological Potters Bar, Hertfordshire EN6 3QG (GB) KITCHIN, Peter Anthony, Nat. Inst. for Biological Potters Bar, Hertfordshire EN6 3QG (GB) MILLS, Kingston H. G., Nat. Inst. for Biological Potters Bar, Hertfordshire EN6 3QG (GB) CHAN, Woon Ling Department of Virology Smithfield London EC1A 7BE (GB) PAGE, Mark, National Institute for Biological Potters Bar, Hertfordshire EN6 3QG (GB) TAFFS, Lesley Frank, National Inst. for Biological Potters Bar, Hertfordshire EN6 3QG (GB) (74) Representative: Woods, Geoffrey Corlett  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)