(19)

(11)

EP 0 650 596 A1

(12)

(43) Date of publication: 03.05.1995 Bulletin 1995/18 (21) Application number: 92917394.0 (22) Date of filing: 30.03.1992

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) A61K 39/ 395( . ) A61K 49/ 00( . ) A61P 35/ 00( . ) C07K 14/ 47( . ) C07K 14/ 705( . ) C07K 16/ 18( . ) C12N 9/ 16( . ) C12P 21/ 08( . ) G01N 33/ 68( . ) A61K 38/ 00( . ) A61K 47/ 48( . ) A61P 3/ 00( . ) C07K 7/ 08( . ) C07K 14/ 575( . ) C07K 16/ 00( . ) C07K 19/ 00( . ) C12N 15/ 02( . ) G01N 33/ 574( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1992/002632 (87) International publication number: WO 1993/020439 (14.10.1993 Gazette 1993/25)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 27.03.1992 US 19920858841 (71) Applicant: THE SCHEPENS EYE RESEARCH INSTITUTE Boston, MA 02114 (US)	(72) Inventor: SCHMIDT, Geoffrey J. Norwell, MA 02061 (US) (74) Representative: Harvey, David Gareth, et al  Graham Watt & Co. Riverhead Sevenoaks Kent TN13 2BN Sevenoaks Kent TN13 2BN (GB)