(19)

(11)

EP 0 650 597 A1

(12)

(43) Date of publication: 03.05.1995 Bulletin 1995/18 (21) Application number: 93916678.0 (22) Date of filing: 22.06.1993

(51) International Patent Classification (IPC):  G01N 33/ 68( . ) G01N 33/ 74( . ) (86) International application number: PCT/US1993/005955 (87) International publication number: WO 1994/000759 (06.01.1994 Gazette 1994/02)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 29.06.1992 US 19920905760 (71) Applicant: UNIVERSITY OF SOUTH FLORIDA Tampa, FL 33620-6250 (US)	(72) Inventors: BERCU, Barry, B. Tampa, FL 33613 (US) WALKER, Richard, F. Indiana Rocks, FL 34635 (US) (74) Representative: Wharton, Peter Robert  Urquhart-Dykes & Lord Inventions House Valley Court, Canal Road Bradford BD1 4SP Bradford BD1 4SP (GB)