(19)

(11)

EP 0 651 795 A1

(12)

(43) Date of publication: 10.05.1995 Bulletin 1995/19 (21) Application number: 91913873.0 (22) Date of filing: 20.06.1991

(51) International Patent Classification (IPC):  C12N 1/ 00( . ) C07K 14/ 475( . ) C07K 16/ 10( . ) C12N 5/ 00( . ) C12N 15/ 00( . ) C12P 13/ 18( . ) C12R 1/ 19( . ) C07K 14/ 01( . ) C07K 14/ 505( . ) C12N 1/ 20( . ) C12N 9/ 64( . ) C12N 15/ 64( . ) C12P 17/ 18( . ) (86) International application number: PCT/US1991/004468 (87) International publication number: WO 1991/019799 (26.12.1991 Gazette 1991/29)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 21.06.1990 US 19900541895 (71) Applicant: THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE Cambridge, MA 02138 (US)	(72) Inventor: THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE Cambridge, MA 02138 (US) (74) Representative: Pett, Christopher Phineas  Frank B. Dehn & Co. European Patent Attorneys Imperial House 15-19 Kingsway London WC2B 6UZ London WC2B 6UZ (GB)