(19)

(11)

EP 0 652 893 A1

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(43) Date of publication: 17.05.1995 Bulletin 1995/20 (21) Application number: 91915557.0 (22) Date of filing: 02.09.1991

(51) International Patent Classification (IPC):  A61K 38/ 55( . ) A61P 25/ 00( . ) A61P 29/ 00( . ) C07K 5/ 02( . ) C07K 5/ 08( . ) C07K 14/ 81( . ) A61P 9/ 02( . ) A61P 25/ 04( . ) A61P 37/ 08( . ) C07K 5/ 06( . ) C07K 5/ 10( . ) (86) International application number: PCT/GB1991/001479 (87) International publication number: WO 1992/004371 (19.03.1992 Gazette 1992/07)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 07.09.1990 GB 19900019558 (71) Applicants: SZELKE, Michael Romsey, Hampshire SO51 OPN (GB) EVANS, David Michael Southampton, Hampshire SO2 1HX (GB) JONES, David Michael West Mellow, Near Romsey, Hampshire SO51 6BY (GB)	(72) Inventors: SZELKE, Michael "Southview" Braishfield Hampshire SO51 0PN (GB) EVANS, David, Michael 114 Adelaide Road St. Denys Hampshire SO2 1HX (GB) JONES, David, Michael "Sundew" Slab Lane Hampshire SO51 6BY (GB) (74) Representative: Farwell, William Robert, et al  PHILLIPS & LEIGH 7 Staple Inn High Holborn London WC1V 7QF London WC1V 7QF (GB)