(19)

(11)

EP 0 652 970 A1

(12)

(43) Date of publication: 17.05.1995 Bulletin 1995/20 (21) Application number: 93911760.0 (22) Date of filing: 30.04.1993

(51) International Patent Classification (IPC):  C12P 17/ 06( . ) A01N 49/ 00( . ) C07D 309/ 38( . ) C12R 1/ 77( . ) A01N 43/ 16( . ) A01N 63/ 04( . ) C12P 17/ 16( . ) (86) International application number: PCT/DK1993/000145 (87) International publication number: WO 1993/022444 (11.11.1993 Gazette 1993/27)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 01.05.1992 DK 19920000583 (71) Applicant: NOVO NORDISK A/S DK-2880 Bagsvaerd (DK)	(72) Inventors: BREINHOLT, Jens DK-2880 Bagsv rd (DK) ROSENDAHL, Connie, Ninna DK-2605 Broendby (DK) DEMUTH, Helle DK-1053 Copenhagen K (DK) (74) Representative: Jensen, Bo Hammer, et al  c/o Novo Nordisk A/S Novo Allé DK-2880 Bagsvaerd DK-2880 Bagsvaerd (DK)