(19)

(11)

EP 0 653 943 A1

(12)

(43) Date of publication: 24.05.1995 Bulletin 1995/21 (21) Application number: 93917068.0 (22) Date of filing: 09.07.1993

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 38/ 00( . ) A61K 48/ 00( . ) A61P 43/ 00( . ) C07K 14/ 705( . ) C12N 5/ 10( . ) C12N 9/ 12( . ) C12N 15/ 113( . ) C12N 15/ 87( . ) A61K 31/ 70( . ) A61K 47/ 48( . ) A61P 29/ 00( . ) C07H 21/ 04( . ) C07K 14/ 715( . ) C12N 9/ 06( . ) C12N 9/ 14( . ) C12N 15/ 85( . ) C12N 15/ 88( . ) (86) International application number: PCT/US1993/006479 (87) International publication number: WO 1994/001139 (20.01.1994 Gazette 1994/03)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 13.07.1992 US 19920912934 (71) Applicant: BAYLOR COLLEGE OF MEDICINE Houston, TX 77030 (US)	(72) Inventor: LEDLEY, Fred, D. Houston, TX 77096 (US) (74) Representative: Patentanwälte Viering, Jentschura & Partner  Postfach 22 14 43 D-80504 München D-80504 München (DE)