(19)

(11)

EP 0 655 888 A1

(12)

(43) Date of publication: 07.06.1995 Bulletin 1995/23 (21) Application number: 93915317.0 (22) Date of filing: 11.06.1993

(51) International Patent Classification (IPC):  A01K 67/ 027( . ) A61P 7/ 08( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) A61K 38/ 16( . ) C07K 14/ 805( . ) C12N 15/ 85( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1993/005629 (87) International publication number: WO 1993/025071 (23.12.1993 Gazette 1993/30)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 12.06.1992 US 19920897648 08.12.1992 US 19920987890 15.03.1993 US 19930030897 (71) Applicant: DNX CORPORATION Princeton, NJ 08450 (US)

(72) Inventors: LOGAN, John, S. Robbinsville, NJ 08691 (US) HOLTZMAN, Steven, H. Princeton Junction, NJ 08550 (US) O'DONNELL, J., Kevin Doylestown, PA 18901 (US) PILDER, Stephen, H. Plainsboro, NJ 08536 (US) PINKERT, Carl, A. Bessemer, AL 35023 (US) SWANSON, Mark, E. Princeton Junction, NJ 08550 (US) KELLER, Hilary Plainsboro, NJ 08536 (US) SHARMA, Ajay Lawrenceville, NJ 08648 (US) PARSONS, Cynthia, T. Plainsboro, NJ 08536 (US) KUMAR, Ramesh Pennington, NJ 08534 (US) WHITE, Steven, P. Highstown, NJ 08520 (US) (74) Representative: Durand, Yves Armand Louis  LAW OFFICES WEINSTEIN 20 Avenue de Friedland F-75008 Paris F-75008 Paris (FR)