(19)

(11)

EP 0 655 913 A1

(12)

(43) Date of publication: 07.06.1995 Bulletin 1995/23 (21) Application number: 94908077.0 (22) Date of filing: 19.08.1993

(51) International Patent Classification (IPC):  A61K 33/ 24( . ) A61P 35/ 00( . ) C07F 17/ 00( . ) A61K 31/ 28( . ) C07F 7/ 28( . ) (86) International application number: PCT/US1993/007875 (87) International publication number: WO 1994/004142 (03.03.1994 Gazette 1994/06)

(84) Designated Contracting States: CH DE FR GB IT LI (30) Priority: 19.08.1992 IL 19920102866 (71) Applicant: KEINAN, Ehud San Diego, CA 92122 (US)	(72) Inventor: KEINAN, Ehud San Diego, CA 92122 (US) (74) Representative: Portal, Gérard, et al  Cabinet Beau de Loménie 158, rue de l'Université F-75340 Paris Cédex 07 F-75340 Paris Cédex 07 (FR)