(19)

(11)

EP 0 655 919 A1

(12)

(43) Date of publication: 07.06.1995 Bulletin 1995/23 (21) Application number: 93920283.0 (22) Date of filing: 23.08.1993

(51) International Patent Classification (IPC):  C07D 491/ 22( . ) A61P 31/ 12( . ) A61K 31/ 47( . ) A61P 37/ 04( . ) (86) International application number: PCT/US1993/007934 (87) International publication number: WO 1994/004160 (03.03.1994 Gazette 1994/06)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 21.08.1992 US 19920933460 19.01.1993 US 19930006320 (71) Applicants: DANA FARBER CANCER INSTITUTE Boston, MA 02115 (US) BETH ISRAEL HOSPITAL Boston, MA 02115 (US)	(72) Inventors: PARDEE, Arthur B. Brookline, MA 02146 (US) LI, Jia-Qiang Boston, Ma 02120 (US) CRUMPACKER, Clyde Gloucester, MA 01930 (US) ZHANG, Lin Boston, MA 02215 (US) (74) Representative: Davies, Jonathan Mark, et al  Reddie & Grose 16 Theobalds Road London WC1X 8PL London WC1X 8PL (GB)