(19)

(11)

EP 0 656 009 A1

(12)

(43) Date of publication: 07.06.1995 Bulletin 1995/23 (21) Application number: 93917672.0 (22) Date of filing: 28.07.1993

(51) International Patent Classification (IPC):  C07D 233/ 64( . ) A61K 38/ 00( . ) C07D 233/ 54( . ) C07K 5/ 078( . ) A61K 31/ 415( . ) A61P 43/ 00( . ) C07K 5/ 02( . ) C07K 5/ 083( . ) (86) International application number: PCT/EP1993/002004 (87) International publication number: WO 1994/003482 (17.02.1994 Gazette 1994/05)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 04.08.1992 IT 1992MI01914 (71) Applicant: ELLEM INDUSTRIA FARMACEUTICA S.R.L. I-20123 Milan (IT)	(72) Inventors: SPORTOLETTI, Giancarlo I-20094 Corsico (IT) DAL POZZO, Alma I-20094 Corsico (IT) (74) Representative: Minoja, Fabrizio  Studio Consulenza Brevettuale, Via Rossini, 8 I-20122 Milano I-20122 Milano (IT)