(19)

(11)

EP 0 656 747 A1

(12)

(43) Date of publication: 14.06.1995 Bulletin 1995/24 (21) Application number: 93920268.0 (22) Date of filing: 20.08.1993

(51) International Patent Classification (IPC):  A61K 48/ 00( . ) C12N 15/ 88( . ) C07K 14/ 47( . ) C12N 15/ 90( . ) (86) International application number: PCT/US1993/007917 (87) International publication number: WO 1994/004032 (03.03.1994 Gazette 1994/06)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 21.08.1992 US 19920933471 (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland, California 94612-3550 (US)	(72) Inventors: GRUENERT, Dieter, C. Mill Valley, CA 94941 (US) KUNZELMANN, Karl San Francisco, CA 95211 (US) (74) Representative: Goldin, Douglas Michael, et al  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)