(19)

(11)

EP 0 656 787 A1

(12)

(43) Date of publication: 14.06.1995 Bulletin 1995/24 (21) Application number: 93920204.0 (22) Date of filing: 18.08.1993

(51) International Patent Classification (IPC):  A61K 31/ 095( . ) A61K 31/ 305( . ) A61K 38/ 00( . ) A61K 39/ 395( . ) A61K 31/ 19( . ) A61K 31/ 415( . ) A61K 38/ 06( . ) (86) International application number: PCT/US1993/007805 (87) International publication number: WO 1994/004185 (03.03.1994 Gazette 1994/06)

(84) Designated Contracting States: FR GB (30) Priority: 19.08.1992 US 19920932369 22.04.1993 US 19930052194 (71) Applicant: TRUSTEES OF BOSTON UNIVERSITY Boston, MA 02115 (US)	(72) Inventor: RYSER, Hugues, J.-P. Concord, MA 01742 (US) (74) Representative: Harvey, David Gareth, et al  Graham Watt & Co. Riverhead Sevenoaks Kent TN13 2BN Sevenoaks Kent TN13 2BN (GB)