(19)

(11)

EP 0 656 947 A1

(12)

(43) Date of publication: 14.06.1995 Bulletin 1995/24 (21) Application number: 93920049.0 (22) Date of filing: 18.08.1993

(51) International Patent Classification (IPC):  C12N 15/ 02( . ) A61K 39/ 395( . ) C07K 14/ 52( . ) C07K 16/ 00( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) A61K 38/ 00( . ) A61P 37/ 00( . ) C07K 14/ 54( . ) C07K 16/ 24( . ) C12N 15/ 24( . ) C12P 21/ 08( . ) (86) International application number: PCT/US1993/007645 (87) International publication number: WO 1994/004680 (03.03.1994 Gazette 1994/06)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 21.08.1992 US 19920933416 29.01.1993 US 19930010977 01.02.1993 US 19930012543 (71) Applicant: SCHERING CORPORATION Kenilworth New Jersey 07033 (US)

(72) Inventors: AVERSA, Gregorio Palo Alto, CA 94301 (US) BANCHEREAU, Jacques La Boissière F-69130 Ecully (FR) BRIERE, Francine F-69210 S.-Germain-sur-l'Arbresle (FR) COOKS, Benjamin, G. Mountain View, CA 94040 (US) COFFMAN, Robert, L. Portola Valley, CA 94025 (US) CULPEPPER, Janice Mountain View, CA 94040 (US) DANG, Warren San Jose, CA 95129 (US) DE VRIES, Jan Los Altos, CA 94022 (US) DE WAAL MALEFYT, Rene Sunnyvale, CA 94086 (US) DOHERTY, Timothy, M. Mountain View, CA 94040 (US) HEATH, Andrew Menlo Park, CA 94025 (US) MCKENZIE, Andrew Redwood City, CA 94061 (US) PUNNONEN, Juha FIN-20720 Turku (FI) ZURAWSKI, Gerard Redwood City, CA 94062 (US) (74) Representative: Ritter, Stephen David, et al  Mathys & Squire 100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)