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(11)

EP 0 658 121 A1

(12)

(43) Date of publication: 21.06.1995 Bulletin 1995/25 (21) Application number: 94908872.0 (22) Date of filing: 23.08.1993

(51) International Patent Classification (IPC):  A61K 47/ 36( . ) A61K 49/ 04( . ) (86) International application number: PCT/US1993/007900 (87) International publication number: WO 1994/005336 (17.03.1994 Gazette 1994/07)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 01.09.1992 US 19920938786 (71) Applicant: STERLING WINTHROP INC. New York, NY 10016 (US)	(72) Inventors: ILLIG, Carl, R. Phoenixville, PA 19460 (US) TONER, John, L. Downingtown, PA 19355 (US) COOPER, Eugene, R. Berwyn, PA 19312 (US) (74) Representative: Woodman, Derek, et al  Frank B. Dehn & Co. European Patent Attorneys Imperial House 15-19 Kingsway London WC2B 6UZ London WC2B 6UZ (GB)