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(11)

EP 0 658 166 A1

(12)

(43) Date of publication: 21.06.1995 Bulletin 1995/25 (21) Application number: 94908867.0 (22) Date of filing: 03.09.1993

(51) International Patent Classification (IPC):  A61K 31/ 70( . ) A61K 31/ 7052( . ) A61K 31/ 7068( . ) A61P 31/ 12( . ) A61K 31/ 7042( . ) A61K 31/ 7064( . ) A61K 31/ 7072( . ) C07H 19/ 06( . ) (86) International application number: PCT/GB1993/001858 (87) International publication number: WO 1994/005687 (17.03.1994 Gazette 1994/07)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 04.09.1992 GB 19920018810 (71) Applicants: THE UNIVERSITY OF BIRMINGHAM Birmingham B15 2TT (GB) THE WELLCOME FOUNDATION LIMITED London NW1 2BP (GB)

(72) Inventors: MILLER, John Allen, The Wellcome Research Lab. Beckenham, Kent BR3 3BS (GB) YOUNG, Robert John, The Wellcome Research Lab. Beckenham, Kent BR3 3BS (GB) RAHIM, Saad George, The Wellcome Research Lab. Beckenham, Kent BR3 3BS (GB) SELWOOD, David Lawrence, The Wellcome Research Lab Beckenham, Kent BR3 3BS (GB) WALKER, Richard, Department of Chemistry Birmingham B15 2TT (GB) (74) Representative: Brasnett, Adrian Hugh  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)