(19)

(11)

EP 0 659 213 A1

(12)

(43) Date of publication: 28.06.1995 Bulletin 1995/26 (21) Application number: 92911122.0 (22) Date of filing: 01.05.1992

(51) International Patent Classification (IPC):  A01K 67/ 027( . ) A61P 3/ 08( . ) A61P 13/ 02( . ) A61P 35/ 00( . ) C07K 14/ 435( . ) C07K 14/ 61( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) C12R 1/ 91( . ) A61K 38/ 27( . ) A61P 9/ 00( . ) A61P 15/ 00( . ) C07K 1/ 00( . ) C07K 14/ 575( . ) C12N 5/ 10( . ) C12N 15/ 85( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1992/003532 (87) International publication number: WO 1992/019736 (12.11.1992 Gazette 1992/28)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 01.05.1991 US 19910693305 (71) Applicant: OHIO UNIVERSITY Athens, OH 45701 (US)	(72) Inventors: KOPCHICK, John, J. Athens, OH 45701 (US) CHEN, Wen, Y. Athens, OH 45701 (US) (74) Representative: Hirsch, Marc-Roger, et al  Cabinet Hirsch 34 rue de Bassano F-75008 Paris F-75008 Paris (FR)