(19)

(11)

EP 0 661 977 A1

(12)

(43) Date of publication: 12.07.1995 Bulletin 1995/28 (21) Application number: 92916470.0 (22) Date of filing: 24.07.1992

(51) International Patent Classification (IPC):  A61K 31/ 47( . ) A61K 31/ 535( . ) C07D 491/ 22( . ) A61K 31/ 495( . ) A61P 35/ 00( . ) (86) International application number: PCT/US1992/006131 (87) International publication number: WO 1993/011770 (24.06.1993 Gazette 1993/15)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE (30) Priority: 10.12.1991 US 19910804570 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406-0939 (US)	(72) Inventor: JOHNSON, Randall, Keith Ardmore, PA 19003 (US) (74) Representative: Tocher, Pauline, et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)