(19)

(11)

EP 0 661 979 A1

(12)

(43) Date of publication: 12.07.1995 Bulletin 1995/28 (21) Application number: 92918930.0 (22) Date of filing: 19.08.1992

(51) International Patent Classification (IPC):  A61K 31/ 70( . ) C07D 487/ 04( . ) C07H 21/ 00( . ) C12N 15/ 09( . ) A61K 48/ 00( . ) C07H 19/ 04( . ) C07H 21/ 04( . ) C12Q 1/ 68( . ) (86) International application number: PCT/US1992/007101 (87) International publication number: WO 1993/003736 (04.03.1993 Gazette 1993/06)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE (30) Priority: 21.08.1991 US 19910748138 (71) Applicant: MICROPROBE CORPORATION Bothell, WA 98021 (US)	(72) Inventors: PETRIE, Charles, R. Woodinville, WA 98072 (US) MEYER, Rich, B., Jr. Woodinville, WA 98072 (US) TABONE, John, C. Bothell, WA 98011 (US) HURST, Gerald, D. The Woodlands, TX 77380 (US) GAMPER, Howard, B. Woodinville, WA 98072 (US) (74) Representative: Draudt, Axel Hermann Christian, Dipl.-Ing., et al  Maiwald & Partner, Poccistrasse 11 D-80336 München D-80336 München (DE)