(19)

(11)

EP 0 662 091 A1

(12)

(43) Date of publication: 12.07.1995 Bulletin 1995/28 (21) Application number: 93921456.0 (22) Date of filing: 10.09.1993

(51) International Patent Classification (IPC):  C07K 14/ 47( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1993/008511 (87) International publication number: WO 1994/006829 (31.03.1994 Gazette 1994/08)

(84) Designated Contracting States: CH DE ES FR GB IT LI (30) Priority: 11.09.1992 US 19920943813 (71) Applicants: INCYTE PHARMACEUTICALS, INC. Palo Alto , CA 94304 (US) MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH Rochester, MN 55905 (US)	(72) Inventors: SCOTT, Randy, W. Sunnyvale, CA 94086 (US) GLEICH, Gerald, J. Rochester, MN 55902 (US) WILDE, Craig, G. Foster City, CA 94404 (US) (74) Representative: Goldin, Douglas Michael, et al  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)