(19)
(11) EP 0 662 475 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
19.07.1995 Bulletin 1995/29

(43) Date of publication A2:
12.07.1995 Bulletin 1995/28

(21) Application number: 94117932.7

(22) Date of filing: 14.11.1994
(51) International Patent Classification (IPC)6: C07D 263/42, C07D 413/04, C07C 255/42, C07D 333/24
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

(30) Priority: 30.12.1993 US 175845
30.12.1993 US 175822

(71) Applicant: AMERICAN CYANAMID COMPANY
Wayne New Jersey 07470 (US)

(72) Inventor:
  • Kameswaran, Venkataraman
    Princeton Junction, New Jersey 08550 (US)

(74) Representative: Wächtershäuser, Günter, Prof. Dr. 
Patentanwalt, Tal 29
80331 München
80331 München (DE)


(56) References cited: : 
   
       


    (54) Method for the preparation of 2-perfluoroalkyl-3-oxazolin-5-one


    (57) There is provided a method for the preparation of a 2-perfluoroalkyl-3-oxazolin-5-one compound of formula (II) comprising reacting an aminonitrile with a perfluoroacylating agent in the presence of a solvent to form a perfluoroalkanoyl aminonitrile intermediate and cyclizing the intermediate in the presence of an acid and at least one molar equivalent of water. Perfluoro-alkanoyl aminonitrile intermediates are also claimed.


    wherein
    n
    is an integer of 1,2,3,4,5,6,7 or 8;
    R
    is

    L
    is hydrogen or halogen.





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