(19)

(11)

EP 0 662 782 A1

(12)

(43) Date of publication: 19.07.1995 Bulletin 1995/29 (21) Application number: 93922763.0 (22) Date of filing: 28.09.1993

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) A61K 39/ 395( . ) A61P 7/ 00( . ) A61P 37/ 06( . ) C07K 14/ 435( . ) C07K 14/ 705( . ) C12N 1/ 21( . ) C12P 21/ 02( . ) C12Q 1/ 68( . ) A61K 39/ 00( . ) A61K 38/ 00( . ) A61K 47/ 48( . ) A61P 29/ 00( . ) A61P 37/ 08( . ) C07K 14/ 47( . ) C07K 16/ 18( . ) C12N 15/ 09( . ) C12P 21/ 08( . ) G01N 33/ 531( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1993/009216 (87) International publication number: WO 1994/007366 (14.04.1994 Gazette 1994/09)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 30.09.1992 US 19920954802 (71) Applicant: TYKOCINSKI, Mark L. Shaker Heights, OH 44122 (US)	(72) Inventor: TYKOCINSKI, Mark L. Shaker Heights, OH 44122 (US) (74) Representative: Patentanwälte Viering, Jentschura & Partner  Postfach 22 14 43 D-80504 München D-80504 München (DE)