(19)

(11)

EP 0 662 829 A1

(12)

(43) Date of publication: 19.07.1995 Bulletin 1995/29 (21) Application number: 93921461.0 (22) Date of filing: 10.09.1993

(51) International Patent Classification (IPC):  A61K 31/ 13( . ) A61P 31/ 12( . ) C07C 211/ 27( . ) C07C 211/ 44( . ) C07C 271/ 20( . ) A61K 31/ 135( . ) C07C 211/ 14( . ) C07C 211/ 29( . ) C07C 211/ 52( . ) (86) International application number: PCT/US1993/008517 (87) International publication number: WO 1994/007480 (14.04.1994 Gazette 1994/09)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.10.1992 GB 19920020921 (71) Applicant: MERRELL DOW PHARMACEUTICALS INC. Cincinnati Ohio 45215-6300 (US)	(72) Inventors: TYMS, A., Stanley Flat 8, 59 Bassett Road London W10 6JR (GB) SNYDER, Ronald, D. Loveland, OH 45149 (US) BOWLIN, Terry, L. Maineville, OH 45039 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 D-81675 München D-81675 München (DE)