(19)

(11)

EP 0 663 831 A1

(12)

(43) Date of publication: 26.07.1995 Bulletin 1995/30 (21) Application number: 92925024.0 (22) Date of filing: 29.10.1992

(51) International Patent Classification (IPC):  C07H 19/ 073( . ) A61K 9/ 70( . ) A61K 31/ 7042( . ) A61K 31/ 7064( . ) A61P 31/ 12( . ) A61K 9/ 00( . ) A61K 31/ 70( . ) A61K 31/ 7052( . ) A61K 47/ 10( . ) (86) International application number: PCT/US1992/009013 (87) International publication number: WO 1993/011775 (24.06.1993 Gazette 1993/15)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL SE (30) Priority: 13.12.1991 US 19910080728 (71) Applicant: G.D. SEARLE & CO. Chicago IL 60680-5110 (US)

(72) Inventors: GRIFFIN, Martin, John McHenry, IL 60050 (US) KARARLI, Tagrul, T. Skokie, IL 60076 (US) KIRCHHOFF, Carol, F. 5630 North Sheridan Road Chicago, IL 60660 (US) PENZOTTI, Stanley, C., Jr. Green Oaks, IL 60048 (US) SCHMIDT, Cynthia, Marie Gurnee, IL 60031 (US) (74) Representative: Beil, Hans Chr., Dr.  BEIL, WOLFF & BEIL, Rechtsanwälte, Postfach 80 01 40 D-65901 Frankfurt D-65901 Frankfurt (DE)